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It is formed by reverse splicing of pre-mRNA, and some circRNAs are abundant and evolutionarily conserved (Misir et al., 2022)

In Giardia and Cryptosporidium sp., triosephosphate isomerase 52 , carbamate kinase 53 , and inosine 5-monophosphate dehydrogenase 54 were evaluated as antiprotozoal drug targets

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doi: 10.2174/1871527313666140806124322 68 PetrosinoS.CordaroM.VerdeR.Schiano MorielloA.MarcolongoG.SchievanoC.et al

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PubMed 28068222 Regulatory status: NAD+ itself is not an approved human medicinal product in any regulatory zone (FDA, EMA, KL)