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Age at baseline and sex were included as fixed effects in the LMMs and individual and study centre were included as random effects, with individual nested under the study centre

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Among compounds discussed in growth-hormone and anti-aging research circles, MK-677 occupies an unusual position: it is orally active, it is not a peptide, and although it generated a substantial body of genuine human clinical data across the 1990s and 2000s, it was never approved as a medicine and its development was ultimately discontinued

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