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The major plant pathway is different from the animal l-ascorbate synthesis pathway that involves 10 enzymatic steps from d-glucose to l-ascorbate via the intermediate formation of GDP-d-mannose and l-galactose [3] (Figure 1a)

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Matrix metalloproteinases (MMPs), a zinc-dependent protease family, is induced by several inflammatory cytokines, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and NO ( In summary, the molecular mechanism of PD is a complicated pathological process involved with abnormal signaling pathway, sophisticated interaction in pro/anti-fibrotic cells, and imbalance between accumulation and degradation of collagen

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Higashimoto T, Baldwin E, Gold JI, Boles RG: Reflex sympathetic dystrophy: Complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance