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J Parenter Drug Assoc

Other mechanisms by which these PPAR agonists prevent oxidative stress include a decrease in iNOS activity, NFB blockade, inhibition of TNF- release, or activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) 138

J Dig Dis 11(6):352357 Kumar M, Kaur P, Chandel M, Singh AP, Jain A, Kaur S (2017) Antioxidant and hepatoprotective potential of Lawsonia inermis L

[DOI] [PMC free article] [PubMed] [Google Scholar] Benovic JL, Khn H, Weyand I, Codina J, Caron MG, Lefkowitz RJ

10.1126/science.1116480 3

Given the pharmacokinetic properties previously described, ICA-1s could potentially be used as an oral therapeutic either with or in place of some therapeutics currently in use