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These compounds help in scavenging the species that initiate the peroxidation, breaking the autoxidative chain reaction, quenching , and preventing the formation of peroxides (Gaschler and Stockwell, 2017)

Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction 8,9,10

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They also acknowledge that this level of complex and sustained treatment may be impossible for many families to take on

Regarding the antioxidant functions, ascorbate acts directly to scavenge oxygen or nitrogen based radical species generated during normal cellular metabolism [10]