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The intracellular environment in macrophages has been strongly associated with the induction of metabolic indolence and antibiotic tolerance 7,8,9,10,11

Guidance from the US Food and Drug Administration includes this lower limit of 30% as a criterion for vaccine licensure
doi: 10.1085/jgp.201711980

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Nausea, fatigue, and reduced appetite frequently occur together at initiation

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