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Skin is the biggest organ of the human body, which provides maintenance of bodily fluid homeostasis and acts as a physical barrier against the entry of microorganisms [39]

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Nrf2 depletion in macrophages leads to increased foam cell formation, increases the M1 inflammatory phenotype with enhanced expression of pro-inflammatory monocyte chemoattractant protein-1 and interleukin-6, and aggravates atherosclerosis (244, 245)
