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These processes establish a vicious cycle wherein dysregulated metabolism and immunosuppression mutually reinforce each other, representing a key mechanism underlying the limited response rates observed with current immunotherapies

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Typical side effects include nausea, headache, facial flushing, and localized hyperpigmentation, generally mild to moderate and self-limiting

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Differences in the structure of plasma low-density lipoproteins and their relationship to the extent of interaction with arterial wall-components