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In acute neuroinflammation mice model, TUDCA specifically reduced microglial activation in the hippocampus, expressions of monocyte chemotactic protein-1 (MCP-1) and vascular cell adhesion 1 (VCAM-1) required for microglial migration and blood monocyte invasion to the CNS inflammation site [131]

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AD is mainly initiated due to the imbalance between the formation and clearance of amyloid- (A) and is characterized by an accumulation of abnormal neuritic plaques and neurofibrillary tangles of hyperphosphorylated tau

This review synthesizes the latest evidence, emphasizing the need for medical supervision, as self-administration carries risks and legal implications in many jurisdictions

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Cu, as the third most abundant transition metal in the brain, plays a critical role in cognitive function by clearing ROS and protecting neurons (210)