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[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Demarest TG, Schuh RA, Waddell J, McKenna MC, Fiskum G

Its role in fatty-acid oxidation is well established in basic science, and its been used clinically for decades in settings where mitochondrial function needs explicit support

[DOI] [Google Scholar] 41.Ong JS, MacGregor S

IVP is a pharmaceutical and nanotechnology development company with a direct practical focus on a clinical research in the fields of ophthalmology, research and development of innovative chemical entities, drug-delivery systems, and unique medical devices to target specific biomedical applications

Carnitine serves a second critical metabolic function, buffering the Coenzyme A pool against accumulation of short chain acetyl-CoAs, which at increasing levels reduce the activity of the pyuvate dehydrogenase complex (PDC)