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Mutations in the gene for TDP-43 cause familial ALS in humans and the ALS-like phenotype in transgenic animals [117]

Interestingly, curcumin can also reduce oxidative stressrelated inflammation induced by lipopolysaccharides (LPS) [69]

This interaction site is also occupied by the GS ligand of iron-sulfur clusters that are bound to class II glutaredoxins 7,15,33,5153