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LCA derivatives exhibit functional dichotomy: 3-oxoLCA antagonizes RORt to inhibit pro-tumor Th17 differentiation, while isoalloLCA promotes Treg generation via mitochondrial reactive oxygen species (mitoROS), a pathway dependent on the Foxp3 locus conserved noncoding sequence 3 (242)

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doi: 10.1016/j.trecan.2021.02.004 Summary Keywords metabolic reprogramming, phosphoglycerate dehydrogenase (PHGDH), serine metabolism, serine synthesis pathway (SSP), targeted therapy, tumor immune microenvironment Citation Su P, Yang Y and Zheng H (2026) The serine code of metabolic reprogramming: multidimensional roles of the serine synthesis pathway in tumors and novel breakthroughs for targeted therapy

What's happening internally: AOD 9604 is binding to receptors, initiating lipolysis, and shifting your metabolism toward fat oxidation

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It hasn't gone away, so can't be because I'm a vegetarian (of nearly 40 years), but I'm guessing that for a long while, they were inclined to think this was the cause