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doi: 10.1016/j.molcel.2014.03.003

Tirzepatide: Nausea and vomiting during dose escalation Fatigue and occasional hypoglycemia (especially if combined with insulin or sulfonylureas) Potential risk of gallbladder issues due to rapid weight loss Cagrilintide: Mild nausea in first two weeks Occasional constipation or reduced appetite beyond comfort No significant hypoglycemia risk Both should be avoided during pregnancy, breastfeeding, or by individuals with personal/family history of medullary thyroid carcinoma (a class precaution for incretin-based therapies)

The original scRNA- seq data generated in this study have been deposited in the gene expression omnibus (GEO) database under accession code GSE253271 The previously published data we used in this study are under accession code: GSE84133 42 , GSE203151 43

Hepatocyte growth factor (HGF) receptor, also known as Met or c-Met, is a class IV RTK that interacts with its specific ligand, HGF, through the Met ectodomain (extracellular domain) to form MetHGF dimers 2,3,4

Diabetes 69 , 267268 (2020)

Prolotherapy is particularly useful for ligament laxity, joint instability, and chronic pain driven by structural weakness