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Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk

S5A) and portal vein (Fig

Structural biology and evolution of the TGF-beta family

Cancers 12 , 394 (2020)

Especially smokers should thus avoid cyanocobalamin and use other forms of B12 instead this will keep their exposure to cyanide down, and will even help with detoxification

Vitamin B12 supplementation helps support normal metabolism, healthy red blood cell production, appetite, growth, recovery, and nervous system function, particularly during periods of increased nutritional demand or deficiency