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If we include the patient who changed from sertraline (no effect) to citalopram (reasonable good effect), no significant difference remains (BF = 0.39) This is only anecdotal evidence that the mechanism via the sigma1 receptor plays a role in the action of SSRI in PCS

Furthermore, HIF-1 may be an indirect player in the promotion of mitochondrial-selective autophagy and may subsequently lower the mitochondrial mass, which inhibits the oxidation of both glucose and fatty acids, and reduces mitochondrial ROS production under hypoxic conditions (40)

We found that monocyte-derived macrophages from individuals with IBD have increased sensitivity to H 2 O 2 -induced ferroptosis and this was at least partially due to decreased expression of GPx1

[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Salice M, Rizzello F, Calabrese C, Calandrini L, Gionchetti P

3, 5, 7) and single particle (Supplementary Figs

The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options