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Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations

ABCC1 exhibits broad substrate specificity(Bakos and Homolya 2007), primarily transporting amphipathic, organic anions, including GSH-, glucuronide- or sulfate-conjugates(Schinkel and Jonker 2012)

Cell 4 , 442444 (2003)

17,18 GSH is not readily imported into cells, and is rapidly cleared from the serum

Hood KY, Montezano AC, Harvey AP, Nilsen M, MacLean MR, Touyz RM

Also, mitochondrial dysfunction was noted in rat lung tissue, and dysregulated mitochondrial dynamics were observed in vitro