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A large biopsy-based study reported that a smoking history of 10 pack-years was significantly associated with advanced fibrosis (adjusted OR 1.63

10.3389/fnins.2014.00182 [DOI] [PMC free article] [PubMed] [Google Scholar] Braun S

& Jiang, T

Pinch approximately 2 to 5 cm of skin to lift the subcutaneous tissue away from underlying muscle

Literature shows that vitamin C is quite vital in periodontitis treatment through erasing oxygen free radicals and improving cellular oxidative status, thereby reducing inflammation and damage to periodontal tissues ( Vitamin E, on the other hand, acts mainly on lipid layers, stabilizing cell membrane structures and preventing lipid peroxidation damage