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This milieu actively suppresses NPPC function, leading to diminished proliferative and differentiation capacities, loss of stemness markers, and a fate skewed towards cell death or senescence [36, 60]

Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats

Le XF, Groner Y, Kornblau SM , Gu Y, Hittelman WN, Levanon D, Mehta K, Arlinghaus RB, Chang KS

Preclinical work points to a mechanism centered on 3-adrenergic receptor modulation, enhanced lipolysis, and reduced lipogenesis, largely independent of the insulin- and IGF-1-related pathways associated with full-length HGH

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However, most other measures, including how participants felt about their sleep, didnt change