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*Correspondence: Panghu Zhou, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Although evidence for some conditions is less robust, NAC's therapeutic potential warrants further investigation

these consensus documents contradict each other

Moreover, they will expedite the discovery of spatially resolved biomarkers that hold substantial clinical translational value

DOI:10.1016/j.coi.2019.05.006 19

Tricarboxylic Acid (TCA) Cycle The TCA (or Krebs) cycle is the central metabolic junction that unites catabolic and anabolic pathways of the three major nutrient classes: carbohydrates, lipids, and amino acids