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The success of fecal microbiota transplantation is most strongly linked to the method of administration, especially when combining both upper and lower gastrointestinal applications [172]

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One such example used an anti-VEGF therapy followed by the inhibition of CA IX activity [107], which was based on the observation that anti-angiogenic therapy exacerbates intratumoral hypoxia leading to induction of CA IX as a survival mechanism

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