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A conformational molecular shift (folded vs un-folded), which increases M6G lipophilicity by masking the polar region, has been proposed to facilitate passive transport across the blood-brain barrier [70]

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The outcome of cell death depends not only on the triggering stimulus but also on cellular metabolism and cell type

DJ1 LOF astrocytes have a pro-inflammatory phenotype and accumulate aggregated proteins To identify pathways that contribute to non-cell-autonomous phenotypes mediated by DJ1 LOF astrocytes, we performed global TMT-proteomics and phospho-proteomics in astrocytes derived from 2 clones (L166P-1 and L166P-2) of KOLF 2.1J DJ1 L166P and their respective CTRs