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Furthermore, severe caloric restriction and weight cycling is shown to be associated with reduced cellular T4 uptake of 25%50%

Portfolio dietary pattern and cardiovascular disease: a systematic review and meta-analysis of controlled trials

Studies of bariatric surgery patients have documented similar phenomena, where rapid weight changes can temporarily exacerbate joint symptoms before eventual improvement occurs

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Sener G, Paskaloglu K, Satiroglu H, Alican I, Kamaz A, Sakarcan AJJocp

Vascular complications of diabetes: mechanisms of injury and protective factors
