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doi: 10.1126/science.2820055 308 SasakiA.FukudaH.ShiidaN.TanakaN.FurugenA.OguraJ.et al

Transfection of astrocytes with the pEGFP-mHtt Q74 plasmid increases Ca 2+ release from lysosomes, which promotes mHTT aggregation, and astrocytes overexpressing mHtt-Q74 show inhibited autophagy [306]

Pregnancy planning : Tirzepatide for weight management should be discontinued if pregnancy occurs or is planned

They help maintain brain health, potentially aiding in preventing neurodegenerative diseases

Auspiciously, we found that PKM2 mediates DRD2-induced GSH production and is selectively expressed in astrocytes, indicating that PKM2 dimerization is an ideal approach to restore GSH synthesis and prevent side effects induced by effects on neuron functions