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Neurology 88(21):2026-35 2017 PMC5440245 Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM, Patricio JL, Peters AL, Pi-Sunyer X, Pownall HJ, Reboussin D, Redmon JB, Steinberg H, Wadden TA, Wagenknecht LE, Wing RR, Womack CR, Yanovski SZ, Zhang P, Schwartz AV, Look AHEAD Study Group

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Fifth, due to lack of reported data, we could not analyze the dietary patterns, medication usage, gut microbiome profiles, L-carnitine bioavailability, or skeletal muscle carnitine content of the patients included in this meta-analysis, which may have had differential effects on the metabolism of L-carnitine