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Several factors can impair B12 absorption: Reduced stomach acid production (achlorhydria or hypochlorhydria), common in older adults and those taking proton pump inhibitors or H2-receptor antagonists long-term, impairs the release of B12 from food proteins Pernicious anaemia , an autoimmune condition destroying parietal cells and reducing intrinsic factor production, completely blocks the primary absorption pathway Gastrointestinal disorders including Crohn's disease, coeliac disease, or surgical removal of stomach or ileum sections directly damage absorption sites Metformin , commonly prescribed for type 2 diabetes, may reduce B12 absorption through unclear mechanisms

These are not interchangeable

Your doctor may monitor treatment response if both medicines are used together

Gastrointestinal malabsorption: Patients with Crohns disease, celiac disease, gastric bypass or intestinal surgery often cant absorb B12 properly

While rare, some individuals may experience minor digestive changes such as mild diarrhea after a B12 shot

Sources: Journal of Translational Medicine , National Library of Medicine Benefits of B12/MIC Lipotropic Injections Boosts energy and discourages onset of fatigue Can help jumpstart weight loss to break through plateaus Shown to help build lean muscle mass Gentle and effective for sensitive stomachs Most effective when combined with a healthy diet and regular exercise Select your plan & get started today