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Exclusion criteria were symptomatic brain metastases, uncontrolled pleural or peritoneal effusions, and inability to interrupt non-steroidal anti-inflammatory drugs

These conditions often pose treatment challenges, with conventional therapies offering limited and temporary relief, significant side effects, and a risk of recurrence

doi: 10.1080/03079450500112195 69

Whereas intracellular metabolites in cluster 5 and 6 rather tended to accumulate upon albumin treatment and consisted predominantly of energy metabolites and co-factors (cluster 5) or lipids (cluster 6) (Fig

Analysis of a family of antibodies with different half-lives in mice fails to find a correlation between affinity for FcRn and serum half-life

Taken together with the current study, which provides mechanistic insight into how KEAP1 mutations rewire tumor metabolism and why glutamine deprivation results in growth suppression, these data provide critical pre-clinical evidence supporting the treatment of patients with KEAP1 mutations with glutaminase inhibitors