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This finding underscores the potential therapeutic value of inhibiting the mtROS/HIF-2 signaling pathway and ameliorating the hypoxic microenvironment to attenuate the detrimental effects of CXCL4 in MS and other CXCL4-driven inflammatory disorders

(2) Do these processes play the same role at both ends of the disease spectrum

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In addition to its potential link to diabetes, PA may also play a protective role against cardiovascular complications associated with the condition

334 found that BM-MSCs secreted IL-10, TGF-, and PGE2 to promote the Treg differentiation by upregulating Foxp3 on the T lymphocyte surface, resulting in a favorable profile of immune components in plaques

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