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The mechanism of action of a successful ADC is depicted in Fig

Some include the alteration of drug targets, expression of drug pumps, expression of de-toxification mechanisms, reduced susceptibility to apoptosis, and increased ability to repair DNA damage, among others

Notably, the CoQ 10 redox system represents a particularly attractive therapeutic node because multiple enzymatic pathways converge to maintain the cellular ubiquinol (CoQ 10 H 2 , reduced) pool

Heleno et al., 2010

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More research is needed in this area though The World Health Organization in its 2007 report on the safety and efficacy of Kava noted: 2.1.3
