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daf-11(m47) carries a nonsense mutation leading to deletion of the entire guanylyl cyclase catalytic domain, which is likely a null mutation 18

Alternative translation initiation generates functionally antagonistic isoformsLAP1 (Liver-enriched Activator Protein 1), LAP2 and LIP (Liver-enriched Inhibitory Protein)which competitively dimerize to fine-tune target gene expression [1719]

WALKER, Harry Earnest WALKER, Lumus E

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