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Upon RA binding, RAR and RXR form a heterodimer, which translocates into the nucleus and binds to retinoic acid response elements (RAREs) on target gene promoters, including ZNF423

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Conversely, excessive SOD activity has been linked with human sperm movement anomalies (96) that may eliminate superoxide, suggesting that SOD plays an important role in sperm movement

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In the past ten years, mounting evidence has collectively demonstrated ferroptosiss significant role in extensive biological and pathological situations, covering anti-viral immunity, aging, and especially cancer suppression [15], thereby making it a glistening and rising star in the fundamental research field of cell biology and basic medicine