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An important finding from animal studies: the minimally effective weight-based dosages determined in rats (2.5-5 ml per kg) are considerably higher than typical human clinical doses

This provides backup if questions or concerns arise

United States Patent 5,164,367, November 1992.

There are also very significant differences in renal structural and functional characteristics in the common laboratory species used for risk assessment

Better Informed Distance Geometry: Using What We Know To Improve Conformation Generation

Biologic drugs target specific immune pathways, but patients may still suffer opportunistic infections and longterm risks like cancer