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The low-carbohydrate, high-fat ketogenic diet provides ketones as energy to mitigate the effects of impaired glucose metabolism in APOE4 carriers [259]

doi: 10.1016/0167-5699(95)80159-6

Myotubes could be induced to hypertrophy by the PI3K/Akt pathway, which increases protein synthesis and blocks the up-regulation of MAFbx and MuRF1 that occurs during muscle atrophy [54, 59]

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