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A study that enrolled adults with diabetes reported that vitamin D insufficiency, defined as levels below 30 ng/mL, is associated with worse self-reported diabetic neuropathy symptoms, and this association persisted even after adjustments were made for several variables, such as obesity or diabetes duration and control (Soderstrom 2012)

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The combination of these three essential amino acids make up approximately 1/3 of skeletal muscle in the human body, and play an important role in protein synthesis

However, in the mouse brain, L-carnitine supplementation has been shown to increase brain 5-HT concentration ( 10 , increased low peripheral serotonin values ( Limitations of the study include a relatively small non-randomized retrospective clinical sample