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Sample size Sample size was based on a standard deviation of 15%, an alpha level of 5%, 80% power, 15% attrition rate and a 16.5% detectable difference in the Comp endpoint between groups based on previous publications [3235]

N-acetyl cysteine (a ROS scavenger) and U0126 (a mitogen-activated protein kinase [MAPK] inhibitor) can rescue PFOS-mediated autophagy activation and, consequently, autophagy-associated apoptosis in RTCs 3

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