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It is well-accepted to increase the critical intracellular antioxidant glutathione, by supplying a stable form of L-cysteine, the rate-limiting factor for glutathione synthesis

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Superoxide dismutase: improved assays and an assay applicable to acrylamide gels

The steady-state concentration of O 2 is about 510 times higher in the mitochondrial matrix than in the cytoplasm or nucleus [39], but the mitochondrial matrix contains Mn-superoxide dismutase (SOD), which can react with O 2 to form hydrogen peroxide (H 2 O 2 ) (Figure 2)

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Dopamine-releasing axons in the nigrostriatal pathway synapse onto GABAergic medium spiny neurons in the striatum