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It is imperative to study and develop pharmacological treatments suitable for the prevention and treatment of COVID-19
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In addition, estrogen metabolism can lead to reactive oxygen species (ROS) and genotoxic metabolites, which may cause DNA damage and tumor development (41, 42)
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Notably, alternative strategies have also been explored, such as LPS/IL-22 co-stimulation to model hyperproliferation [41], LPS/TNF- for inflammatory responses [42], TNF-/IL-17 A combination [43] IL-22/TNF- co-treatment [44], or IMQ application [45]
