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Nienaber A, Ozturk M, Dolman R, Blaauw R, Zandberg LL, van Rensburg S, Britz M, Hayford FEA, Brombacher F, Loots DT, et al

Jodeiri Farshbaf M, Ghaedi K

120 ROS play crucial modulatory roles in amplifying distal TCR pathways, including Ca 2+ -calcineurin-NFAT, IKK-NF-B, Ras-ERK1/2, and mTOR cascades, which in turn enhance T-cell activation, proliferation, and cytokine production (e.g., IL-2)

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As with most RTKs, IGF-1R acts as a node in a complex web of robust signaling networks [72, 73]

802 Notably, GSH is released from the ischemic area into the extracellular space after I/R, accompanied by a decrease in intracellular GSH concentration