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Oxidized fat was shown to upregulate PPAR and OCNT2 and lead to reduced rate of weight gain compared to controls, indicating an impairment of the feed conversion ratio [112]

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The normal alignment of myofibers was frequently disrupted by the accumulation of edematous fluid, and darker red-staining myocytes indicated necrotic regions

Because of the lack of agreement on the definition and diagnostic assessment of neuropathy, several consensus conferences were convened to overcome the current problems, the most recent of which has re-defined the minimal criteria for the diagnosis of typical DSPN as summarized below 14