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Therefore, under this situation, further increasing PROTAC binding affinities to BTK, such as comparing RC-1 and RNC-1, would not lead to a meaningful increase of ternary complex formation

This problem gets worse if you also dont have enough iron

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GHK Cu ,

GHK-Cu's copper ion can catalyze oxidation reactions that break down BPC-157 and TB-500 in the same solution
