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Subsequently, under ATP consumption, the adenylation of the formed MET leads to the formation of S-adenosyl-L-methionine (SAM), which serves as a central molecule fueling all methylation reactions, including DNA and histone methylation, by donation of a methyl group [10]

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CBT explicitly teaches the individual to identify where they are in the cycle for example, recognising that a thought such as nobody likes me contributes to feelings of sadness and behaviours such as withdrawal and then to examine and challenge that thought