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Recent studies have revealed that hydropersulfides also play a role in preventing ferroptosis by capturing radicals and engaging in autolytic regeneration mechanisms

Deletion of the yeast CTR1 gene reduces the intracellular accumulation of cisplatin and leads to cisplatin-resistance (Ishida et al., 2002), while forced overexpression of hCTR1 sensitizes small cell lung cancer cells to cisplatin, carboplatin, and oxaliplatin (Song et al., 2004)

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The contrasting outcomes of rescue at 10 h vs