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530 Given the elevated activity of monoamine oxidase-B (MAO-B) observed in AD, dual inhibition of AChE and MAO-B holds promise for synergistic effects on cholinergic system recovery and A plaque formation, along with potential benefits in alleviating oxidative stress injury

Discher DE, Eisenberg A

Rheumatology 60 , 20662074 (2021)

We begin with the lowest effective dose of any intervention, monitor closely, and adjust incrementally
Regular physician follow-ups to assess sleep quality improvements, monitor recovery benefits, adjust protocols as needed, and ensure optimal therapeutic outcomes for sleep wellness

Furthermore, rather than utilizing high dosages that do not occur in the natural environment, the exposure evaluation should be based on the environment-relevant-concentrations (ERCs) of the chemicals (Kabir et al., 2015)
