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Along with resistance to treatment in some patients with glioblastoma, the inability to cross the bloodbrain barrier (BBB) is deemed another flaw of such methods of treatment [30]

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In diabetic conditions, blood polymorphonuclear leukocytes (PMNs) demonstrate increased mtROS production [27], reduced oxygen consumption [28], and decreased rolling velocity [29], which correlates with an enhanced interaction with endothelial cells

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This makes them mechanistically distinct even though both are grouped under GH secretagogue research

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