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By increasing the expression of Vascular Endothelial Growth Factor (VEGF), it creates a richer blood supply in areas that are traditionally dead zones for circulation, like the ACL or the Achilles tendon [2, 7]

FDA NEWS RELEASE, FDA Approves First Interchangeable Biosimilar Insulin Product for Treatment of Diabetes

the evidence is mostly older and preclinical with limited independent replication

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10.1016/j.yexcr.2017.10.034 269 WuF.YeH.LinJ.XuY.ZhangZ.XiongH.et al (2018a)

The pharmacodynamic concepts of maximum response and sensitivity determine the magnitude of the effect at a particular concentration (see E max and C 50 , Chapter 2