glutathione therapy from prodrugs to genes Frontiers Ultrasound-Controlled Prodrug Activation: Emerging Strategies

For this reason, the phosphonate parent compound, HEX, is substantially less toxic to uninfected erythrocytes but retains antiparasitic activity ( Table 1 ), predicting a wider therapeutic index in vivo

As expected, we observed greater expression of dedifferentiation signatures within the relapse group compared to the control both in the tumors and in tumor-derived cell lines (Figure 2D)

10.3892/etm.2017.4573 90 LiuJ.WangJ.XiongA.ZhangL.ZhangY.LiuY.et al (2023a)

Importantly, ferroptosis is caspase independent and occurs when the antioxidant defense system, primarily the system Xc-/GSH/GPX4 axis, is compromised

[DOI] [PubMed] [Google Scholar] 20.Hayes P.C., Bouchier I.A., Beckett G.J

Natl Inst Ment Health NIMH