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Yang HP, Ramani K, Xia M, Ko KS, Li TWH, Oh P, Li J, Lu SC (2009) Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications

Eight weeks of methyl-donor supplementation at 4 weeks of age in female rats reduced oxidative stress, as measured by the nitrite content in the rat hippocampus, reduced anxiety-like behavior in the elevated plus maze test, and depressive-like behavior in the forced swimming test, reinforcing the notion that methyl donors could act as nutri-therapeutic agents in mitigating the effects of stress-related disorders such as anxiety and depression [133]

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