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Long-term continuous use without breaks may lead to reduced effectiveness
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drc.bmj.comZ Miyan, N WarisBMJ Open Diabetes Research & Care, 2020drc.bmj.com 8:1151 Hasan NU, Makki U, Abid I, Ur M, Abid Butt R Association of vitamin B12 deficiency with intake of oral metformin in diabetic patients
Absorption and Effectiveness TB-500 Nasal Spray: Nasal spray offers the convenience of drug delivery to the brain via the cribriform plate from the nostrils, allowing direct access, as well as facilitating systemic absorption through local blood vessels for broader effects throughout the body

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They are not interchangeable with or categorically comparable to Lipo-B or Lipo-C formulations