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Dopamine oxidation, through the endogenous production of various neurotoxic metabolitessuch as dopamine quinones and thio-catecholaminestriggers a cascade of molecular events leading to cell death, with a high specificity for dopaminergic neurons in the substantia nigra

Circulation (2016) 133(8):698705

Neuropsychiatric effects have been reported in post-marketing surveillance of GLP-1 receptor agonists, though the incidence and causal relationship remain unclear

Exercise epigenetics is fueled by cell bioenergetics: supporting role on brain plasticity and cognition

Moreover, increased AMP levels result in the inhibition of the activity of enzymes that are regulated by AMP and are involved in gluconeogenesis, such as adenylate cyclase and fructose-1-6-bisphosphatase (FBP1), which contributes to reducing glucose output [31]

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