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Both these compounds work by reducing the formation of the MSH hormone to minimise hyperpigmentation 1

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Nrf2-ARE, nuclear factor erythroid 2-antioxidant responsive element

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The essential role of OmpR in Acidithiobacillus caldus adapting to the high osmolarity and its regulation on the tetrathionate-metabolic pathway

Organisms sense these regular external changes and synchronize their physical activities, such as behavior, food intake, energy metabolism, sleep, reproductive activity, and immune function, to increase their survival abilities (Takahashi et al., 2008)