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Additionally, morronoside significantly inhibited SOD1 activity and the percentage of cells in apoptosis in a dose-dependent manner [145]

This was mediated through disruption of microbiota-gut-brain axis homeostasis, specifically manifested as reduced production of serotonin (5-HT) in the gut, leading to lower levels transported to the brain via the bloodstream, ultimately contributing to neurobehavioral deficits

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S., Ittmann, M., Kadmon, D., Thompson, T
